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Pyridoxine Dependent Epilepsy

Pyridoxine Dependent Epilepsy (PDE)


The ‘building blocks’ of protein are called amino acids. In Pyridoxine Dependent Epilepsy (PDE), due to the lack of an enzyme, the body cannot properly deal with one of the amino acids, lysine. The disorder is characterized by intractable seizures in early life plus the longer-term outcomes of intellectual and developmental delays. People with PDE therefore need to restrict the amount of protein they eat.

A key element in the management of PDE is the use of protein substitutes. Protein substitutes for PDE provide all the amino acids found in protein but no lysine. In combination with their allowance of regular dietary protein, protein substitutes ensure that an individual with PDE has an adequate intake of protein.

Vitaflo produces a specific, lifestyle-friendly and palatable protein substitute for PDE.

Our product range for PDE

Inborn Errors of Metabolism 

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